| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,062,365,282.64 | 23.0365 | 16.863 | 06/30/2025 |
| 2 | Westfield Capital Management Co. LP | 5,451,401 | -27,858 | 1,093,496,526.59 | 4.2917 | 8.941 | 06/30/2025 |
| 3 | Avoro Capital Advisor LLC | 4,980,000 | -238,000 | 998,938,200 | 12.473 | 8.1679 | 06/30/2025 |
| 4 | Janus Henderson Investors US LLC | 4,328,772 | -81,372 | 868,308,375.48 | 0.4111 | 7.0998 | 06/30/2025 |
| 5 | Fidelity Management & Research Co. LLC | 4,178,937 | -125,408 | 838,252,972.83 | 0.0468 | 6.854 | 06/30/2025 |
| 6 | Artisan Partners LP | 3,990,424 | -266,203 | 800,439,150.16 | 0.6083 | 6.5448 | 06/30/2025 |
| 7 | T. Rowe Price Investment Management, Inc. | 3,583,546 | 529,722 | 718,823,492.14 | 0.4253 | 5.8775 | 06/30/2025 |
| 8 | Capital Research & Management Co. (International Investors) | 3,046,931 | 172,139 | 611,183,889.29 | 0.0949 | 4.9974 | 06/30/2025 |
| 9 | T. Rowe Price Associates, Inc. (IM) | 1,875,491 | -380,611 | 376,204,739.69 | 0.0433 | 3.0761 | 06/30/2025 |
| 10 | Massachusetts Financial Services Co. | 1,819,476 | 28,306 | 364,968,690.84 | 0.1109 | 2.9842 | 06/30/2025 |
| 11 | Franklin Advisers, Inc. | 1,255,662 | 177,346 | 251,873,240.58 | 0.1108 | 2.0595 | 06/30/2025 |
| 12 | Perceptive Advisors LLC | 963,886 | 963,886 | 193,345,892.74 | 4.6621 | 1.5809 | 06/30/2025 |
| 13 | Invesco Advisers, Inc. | 911,370 | -246,458 | 182,811,708.3 | 0.0743 | 1.4948 | 06/30/2025 |
| 14 | Wellington Management Co. LLP | 879,046 | 329,621 | 176,327,837.14 | 0.0284 | 1.4418 | 06/30/2025 |
| 15 | Polar Capital LLP | 837,777 | 312,777 | 168,049,688.43 | 0.4638 | 1.3741 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MFS Mid Cap Growth Fund | 1,282,886 | -21,727 | 257,334,102.74 | 1.6956 | 2.1041 | 08/31/2025 |
| 2 | American Funds Growth Fund of America | 1,062,134 | 0 | 213,053,459.06 | 0.0637 | 1.742 | 09/30/2025 |
| 3 | T Rowe Price Mid Cap Growth Fund | 1,015,400 | -4,600 | 203,679,086 | 0.7478 | 1.6654 | 09/30/2025 |
| 4 | Janus Henderson Enterprise Fund | 976,876 | 0 | 195,951,556.84 | 0.8304 | 1.6022 | 06/30/2025 |
| 5 | T Rowe Price Health Sciences Fund | 836,811 | -111,500 | 167,855,918.49 | 1.4404 | 1.3725 | 09/30/2025 |
| 6 | Vanguard Health Care Fund | 825,672 | 825,672 | 165,621,546.48 | 0.425 | 1.3542 | 07/31/2025 |
| 7 | Artisan Mid Cap Fund | 818,052 | -120,800 | 164,093,050.68 | 4.2169 | 1.3417 | 09/30/2025 |
| 8 | Fidelity Select Port. - Health Care Portfolio | 740,000 | -10,000 | 148,436,600 | 2.3129 | 1.2137 | 08/31/2025 |
| 9 | American Funds New Perspective Fund | 623,163 | 0 | 125,000,266.17 | 0.0784 | 1.0221 | 09/30/2025 |
| 10 | Bridge Builder Small/Mid Cap Growth Fund | 621,871 | 70,067 | 124,741,103.89 | 1.3169 | 1.02 | 09/30/2025 |
| 11 | Franklin DynaTech Fund | 600,000 | 400,000 | 120,354,000 | 0.4075 | 0.9841 | 09/30/2025 |
| 12 | Fidelity Select Port. - Biotechnology Portfolio | 582,501 | -76,908 | 116,843,875.59 | 2.3885 | 0.9554 | 08/31/2025 |
| 13 | American Funds Small Cap World Fund | 579,165 | 0 | 116,174,707.35 | 0.1472 | 0.9499 | 09/30/2025 |
| 14 | Harbor Small Cap Growth Fund | 535,777 | -84,613 | 107,471,508.43 | 5.008 | 0.8787 | 07/31/2025 |
| 15 | CTIVP - Morgan Stanley Advantage Fund | 531,777 | -100,200 | 106,669,148.43 | 5.694 | 0.8722 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Perceptive Advisors LLC | 963,886 | 963,886 | 193,345,892.74 | 4.6621 | 1.5809 | 06/30/2025 |
| 2 | T. Rowe Price Investment Management, Inc. | 3,583,546 | 529,722 | 718,823,492.14 | 0.4253 | 5.8775 | 06/30/2025 |
| 3 | Wellington Management Co. LLP | 879,046 | 329,621 | 176,327,837.14 | 0.0284 | 1.4418 | 06/30/2025 |
| 4 | Polar Capital LLP | 837,777 | 312,777 | 168,049,688.43 | 0.4638 | 1.3741 | 06/30/2025 |
| 5 | Franklin Advisers, Inc. | 1,255,662 | 177,346 | 251,873,240.58 | 0.1108 | 2.0595 | 06/30/2025 |
| 6 | Capital Research & Management Co. (International Investors) | 3,046,931 | 172,139 | 611,183,889.29 | 0.0949 | 4.9974 | 06/30/2025 |
| 7 | Lord, Abbett & Co. LLC | 154,176 | 154,176 | 30,926,163.84 | 0.0853 | 0.2529 | 06/30/2025 |
| 8 | Adage Capital Management LP | 459,606 | 132,201 | 92,192,367.54 | 0.1438 | 0.7538 | 06/30/2025 |
| 9 | Summit Partners Public Asset Management LLC | 130,000 | 130,000 | 26,076,700 | 0.8841 | 0.2132 | 06/30/2025 |
| 10 | Macquarie Investment Management Business Trust | 116,735 | 116,735 | 23,415,873.65 | 0.0237 | 0.1915 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Morgan Stanley & Co. LLC | 194,168 | -1,670,516 | 38,948,159.12 | 0.013 | 0.3185 | 06/30/2025 |
| 2 | Point72 Asset Management LP | 0 | -581,199 | 0 | 0 | 0 | |
| 3 | Citadel Advisors LLC | 587,270 | -537,824 | 117,800,489.3 | 0.13 | 0.9632 | 06/30/2025 |
| 4 | T. Rowe Price Associates, Inc. (IM) | 1,875,491 | -380,611 | 376,204,739.69 | 0.0433 | 3.0761 | 06/30/2025 |
| 5 | Artisan Partners LP | 3,990,424 | -266,203 | 800,439,150.16 | 0.6083 | 6.5448 | 06/30/2025 |
| 6 | Invesco Advisers, Inc. | 911,370 | -246,458 | 182,811,708.3 | 0.0743 | 1.4948 | 06/30/2025 |
| 7 | Avoro Capital Advisor LLC | 4,980,000 | -238,000 | 998,938,200 | 12.473 | 8.1679 | 06/30/2025 |
| 8 | Millennium Management LLC | 72,888 | -191,979 | 14,620,603.92 | 0.0122 | 0.1195 | 06/30/2025 |
| 9 | Finepoint Capital LP | 0 | -179,872 | 0 | 0 | 0 | |
| 10 | Saturn V Capital Management LP | 38,191 | -161,073 | 7,660,732.69 | 1.5822 | 0.0626 | 06/30/2025 |
Data provided by FactSet Research Systems Inc.