| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 168,752 | 1,730,478,591.76 | 24.3777 | 16.863 | 03/31/2025 |
| 2 | Westfield Capital Management Co. LP | 5,479,259 | -48,980 | 922,214,082.29 | 3.725 | 8.9867 | 03/31/2025 |
| 3 | Avoro Capital Advisor LLC | 5,218,000 | 114,945 | 878,241,580 | 13.2703 | 8.5582 | 03/31/2025 |
| 4 | Janus Henderson Investors US LLC | 4,410,144 | 45,775 | 742,271,336.64 | 0.3669 | 7.2332 | 03/31/2025 |
| 5 | Fidelity Management & Research Co. LLC | 4,304,345 | -52,567 | 724,464,306.95 | 0.0421 | 7.0597 | 03/31/2025 |
| 6 | Artisan Partners LP | 4,256,627 | -193,793 | 716,432,890.37 | 0.5688 | 6.9814 | 03/31/2025 |
| 7 | T. Rowe Price Investment Management, Inc. | 3,053,824 | 328,278 | 513,989,117.44 | 0.3119 | 5.0087 | 03/31/2025 |
| 8 | Capital Research & Management Co. (International Investors) | 2,874,792 | 11,543 | 483,856,241.52 | 0.0787 | 4.715 | 03/31/2025 |
| 9 | T. Rowe Price Associates, Inc. (IM) | 2,256,102 | -27,105 | 379,724,527.62 | 0.0451 | 3.7003 | 03/31/2025 |
| 10 | Morgan Stanley & Co. LLC | 1,864,684 | 1,082,087 | 313,844,964.04 | 0.1077 | 3.0583 | 03/31/2025 |
| 11 | Massachusetts Financial Services Co. | 1,791,170 | 10,309 | 301,471,822.7 | 0.0925 | 2.9378 | 03/31/2025 |
| 12 | Invesco Advisers, Inc. | 1,157,828 | 42,970 | 194,874,030.68 | 0.08 | 1.899 | 03/31/2025 |
| 13 | Citadel Advisors LLC | 1,125,094 | 234,561 | 189,364,571.14 | 0.2366 | 1.8453 | 03/31/2025 |
| 14 | Franklin Advisers, Inc. | 1,078,316 | 315,923 | 181,491,365.96 | 0.0834 | 1.7686 | 03/31/2025 |
| 15 | Columbia Management Investment Advisers LLC | 679,931 | -22,630 | 114,439,186.61 | 0.03 | 1.1152 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | MFS Mid Cap Growth Fund | 1,304,613 | -14,221 | 219,579,414.03 | 1.4088 | 2.1397 | 05/31/2025 |
| 2 | American Funds Growth Fund of America | 1,062,134 | -1,775 | 178,767,773.54 | 0.0564 | 1.742 | 06/30/2025 |
| 3 | T Rowe Price Mid Cap Growth Fund | 1,018,800 | -2,800 | 171,474,228 | 0.608 | 1.671 | 06/30/2025 |
| 4 | Janus Henderson Enterprise Fund | 976,876 | 0 | 164,417,999.56 | 0.7087 | 1.6022 | 03/31/2025 |
| 5 | Artisan Mid Cap Fund | 875,646 | -93,129 | 147,379,978.26 | 3.8364 | 1.4362 | 06/30/2025 |
| 6 | Fidelity Select Port. - Health Care Portfolio | 740,000 | -10,000 | 124,549,400 | 2.1162 | 1.2137 | 05/31/2025 |
| 7 | T Rowe Price Health Sciences Fund | 693,353 | -314,209 | 116,698,243.43 | 1.03 | 1.1372 | 06/30/2025 |
| 8 | CTIVP - Morgan Stanley Advantage Fund | 631,977 | -22,445 | 106,368,048.87 | 5.4772 | 1.0365 | 03/31/2025 |
| 9 | Bridge Builder Small/Mid Cap Growth Fund | 624,675 | 122,580 | 105,139,049.25 | 1.1079 | 1.0246 | 06/30/2025 |
| 10 | American Funds New Perspective Fund | 623,163 | -866 | 104,884,564.53 | 0.0681 | 1.0221 | 06/30/2025 |
| 11 | Fidelity Select Port. - Biotechnology Portfolio | 597,809 | -61,600 | 100,617,232.79 | 2.4771 | 0.9805 | 05/31/2025 |
| 12 | Harbor Small Cap Growth Fund | 587,686 | 70,486 | 98,913,430.66 | 4.7691 | 0.9639 | 04/30/2025 |
| 13 | American Funds Small Cap World Fund | 579,165 | 0 | 97,479,261.15 | 0.1272 | 0.9499 | 06/30/2025 |
| 14 | T Rowe Price New Horizons Fund | 573,396 | -70,197 | 96,508,280.76 | 0.6259 | 0.9404 | 06/30/2025 |
| 15 | Polar Capital Funds Plc - Biotechnology Fund | 495,000 | 195,000 | 83,313,450 | 4.3182 | 0.8119 | 05/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Morgan Stanley & Co. LLC | 1,864,684 | 1,082,087 | 313,844,964.04 | 0.1077 | 3.0583 | 03/31/2025 |
| 2 | T. Rowe Price Investment Management, Inc. | 3,053,824 | 328,278 | 513,989,117.44 | 0.3119 | 5.0087 | 03/31/2025 |
| 3 | Adage Capital Management LP | 327,405 | 327,405 | 55,105,535.55 | 0.0904 | 0.537 | 03/31/2025 |
| 4 | Franklin Advisers, Inc. | 1,078,316 | 315,923 | 181,491,365.96 | 0.0834 | 1.7686 | 03/31/2025 |
| 5 | Citadel Advisors LLC | 1,125,094 | 234,561 | 189,364,571.14 | 0.2366 | 1.8453 | 03/31/2025 |
| 6 | Polar Capital LLP | 525,000 | 225,000 | 88,362,750 | 0.2747 | 0.8611 | 03/31/2025 |
| 7 | RA Capital Management LP | 10,281,496 | 168,752 | 1,730,478,591.76 | 24.3777 | 16.863 | 03/31/2025 |
| 8 | PFM Health Sciences LP | 186,916 | 134,524 | 31,459,831.96 | 2.4639 | 0.3066 | 03/31/2025 |
| 9 | Avoro Capital Advisor LLC | 5,218,000 | 114,945 | 878,241,580 | 13.2703 | 8.5582 | 03/31/2025 |
| 10 | Braidwell LP | 106,713 | 106,713 | 17,960,865.03 | 0.6338 | 0.175 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Camber Capital Management LP | 350,000 | -450,000 | 58,908,500 | 4.0149 | 0.574 | 03/31/2025 |
| 2 | Vestal Point Capital LP | 150,142 | -369,858 | 25,270,400.02 | 1.6033 | 0.2463 | 03/31/2025 |
| 3 | FIL Investments International | 457,988 | -265,270 | 77,083,960.28 | 0.0577 | 0.7512 | 03/31/2025 |
| 4 | Artisan Partners LP | 4,256,627 | -193,793 | 716,432,890.37 | 0.5688 | 6.9814 | 03/31/2025 |
| 5 | Alyeska Investment Group LP | 42,416 | -112,584 | 7,139,036.96 | 0.0252 | 0.0696 | 03/31/2025 |
| 6 | Wellington Management Co. LLP | 549,425 | -107,731 | 92,473,721.75 | 0.0153 | 0.9011 | 03/31/2025 |
| 7 | Duquesne Family Office LLC | 158,720 | -106,320 | 26,714,163.2 | 0.7502 | 0.2603 | 03/31/2025 |
| 8 | Millennium Management LLC | 264,867 | -93,277 | 44,579,764.77 | 0.0385 | 0.4344 | 03/31/2025 |
| 9 | Marshall Wace LLP | 22,294 | -91,951 | 3,752,303.14 | 0.0043 | 0.0366 | 03/31/2025 |
| 10 | Rock Springs Capital Management LP | 216,000 | -89,000 | 36,354,960 | 1.9099 | 0.3543 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.