| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Fidelity Management & Research Co. LLC | 5,360,840 | 58,154 | 3,084,734,552.8 | 0.1794 | 8.8228 | 03/31/2025 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 4,590,184 | -112,997 | 2,641,283,677.28 | 0.3143 | 7.5545 | 03/31/2025 |
| 3 | Artisan Partners LP | 2,785,890 | -284,105 | 1,603,056,823.8 | 1.2756 | 4.585 | 03/31/2025 |
| 4 | Janus Henderson Investors US LLC | 2,141,936 | -168,750 | 1,232,512,813.12 | 0.6104 | 3.5252 | 03/31/2025 |
| 5 | Capital Research & Management Co. (World Investors) | 1,937,992 | 151,056 | 1,115,159,356.64 | 0.117 | 3.1895 | 03/31/2025 |
| 6 | Avoro Capital Advisor LLC | 1,235,177 | -3,290 | 710,745,549.34 | 10.6966 | 2.0328 | 03/31/2025 |
| 7 | T. Rowe Price International Ltd. | 794,402 | -19,311 | 457,114,798.84 | 0.291 | 1.3074 | 03/31/2025 |
| 8 | RTW Investments LP | 673,497 | 0 | 387,543,643.74 | 5.5168 | 1.1084 | 03/31/2025 |
| 9 | ClearBridge Investments LLC | 664,368 | 34,540 | 382,290,634.56 | 0.2804 | 1.0934 | 03/31/2025 |
| 10 | Bellevue Asset Management AG | 578,874 | -14,310 | 333,095,677.08 | 5.7348 | 0.9527 | 03/31/2025 |
| 11 | Citadel Advisors LLC | 541,943 | 35,268 | 311,844,841.06 | 0.3878 | 0.8919 | 03/31/2025 |
| 12 | Morgan Stanley & Co. LLC | 498,552 | -68,144 | 286,876,791.84 | 0.0982 | 0.8205 | 03/31/2025 |
| 13 | Invesco Advisers, Inc. | 365,323 | -21,757 | 210,214,160.66 | 0.0863 | 0.6012 | 03/31/2025 |
| 14 | SEI Investments Management Corp. | 361,000 | -5,620 | 207,726,620 | 0.2198 | 0.5941 | 03/31/2025 |
| 15 | Wellington Management Co. LLP | 343,563 | -15,242 | 197,693,021.46 | 0.0328 | 0.5654 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | American Funds EuroPacific Growth Fund | 1,116,241 | -48,347 | 642,307,396.22 | 0.4972 | 1.8371 | 06/30/2025 |
| 2 | Fidelity Growth Company Commingled Pool | 876,491 | 3,469 | 504,350,451.22 | 0.5244 | 1.4425 | 05/31/2025 |
| 3 | T Rowe Price Health Sciences Fund | 736,981 | -45,117 | 424,073,607.02 | 3.4832 | 1.2129 | 03/31/2025 |
| 4 | Fidelity Growth Company Fund | 627,063 | 281 | 360,824,591.46 | 0.5057 | 1.032 | 05/31/2025 |
| 5 | T Rowe Price New Horizons Fund | 624,306 | -172,194 | 359,238,158.52 | 2.3225 | 1.0275 | 06/30/2025 |
| 6 | T Rowe Price Growth Stock Fund | 552,622 | -108,341 | 317,989,751.24 | 0.6162 | 0.9095 | 06/30/2025 |
| 7 | Janus Henderson Forty Fund | 534,577 | -76,704 | 307,606,297.34 | 1.2769 | 0.8798 | 03/31/2025 |
| 8 | Fidelity OTC Portfolio | 440,026 | 119,416 | 253,199,760.92 | 0.7849 | 0.7242 | 05/31/2025 |
| 9 | American Funds New Economy Fund | 410,022 | 83,418 | 235,934,859.24 | 0.6361 | 0.6748 | 06/30/2025 |
| 10 | Fidelity Contrafund | 336,180 | -7,000 | 193,444,695.6 | 0.1148 | 0.5533 | 05/31/2025 |
| 11 | Artisan Mid Cap Fund | 290,676 | -44,553 | 167,260,783.92 | 4.3746 | 0.4784 | 06/30/2025 |
| 12 | Janus Henderson Enterprise Fund | 284,627 | -21,350 | 163,780,068.34 | 0.7043 | 0.4684 | 03/31/2025 |
| 13 | Fidelity Select Port. - Health Care Portfolio | 280,000 | -20,000 | 161,117,600 | 2.7072 | 0.4608 | 05/31/2025 |
| 14 | Invesco Developing Markets Fund | 247,742 | -59,258 | 142,555,701.64 | 0.9215 | 0.4077 | 05/31/2025 |
| 15 | T Rowe Price Large Cap Growth Fund | 243,800 | -24,252 | 140,287,396 | 0.6042 | 0.4012 | 06/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Millennium Management LLC | 268,604 | 204,180 | 154,560,113.68 | 0.133 | 0.4421 | 03/31/2025 |
| 2 | Capital Research & Management Co. (World Investors) | 1,937,992 | 151,056 | 1,115,159,356.64 | 0.117 | 3.1895 | 03/31/2025 |
| 3 | BNP Paribas Financial Markets | 133,359 | 123,127 | 76,737,435.78 | 0.0516 | 0.2195 | 03/31/2025 |
| 4 | UBS Securities LLC | 101,032 | 81,834 | 58,135,833.44 | 0.0235 | 0.1663 | 03/31/2025 |
| 5 | Braidwell LP | 160,849 | 80,083 | 92,555,731.58 | 3.2559 | 0.2647 | 03/31/2025 |
| 6 | Assenagon Asset Management SA (Germany) | 112,057 | 77,102 | 64,479,838.94 | 0.0917 | 0.1844 | 06/30/2025 |
| 7 | Two Sigma Investments LP | 73,948 | 73,948 | 42,551,158.16 | 0.0818 | 0.1217 | 03/31/2025 |
| 8 | Qube Research & Technologies Ltd. | 77,996 | 71,300 | 44,880,458.32 | 0.062 | 0.1284 | 03/31/2025 |
| 9 | Bank of America, NA (Private Banking) | 75,212 | 70,883 | 43,278,489.04 | 0.0143 | 0.1238 | 03/31/2025 |
| 10 | Lord, Abbett & Co. LLC | 274,700 | 68,498 | 158,067,874 | 0.4585 | 0.4521 | 03/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Paradigm BioCapital Advisors LP | 59,679 | -421,626 | 34,340,490.18 | 1.408 | 0.0982 | 03/31/2025 |
| 2 | T. Rowe Price Investment Management, Inc. | 80,647 | -407,206 | 46,405,896.74 | 0.0282 | 0.1327 | 03/31/2025 |
| 3 | Artisan Partners LP | 2,785,890 | -284,105 | 1,603,056,823.8 | 1.2756 | 4.585 | 03/31/2025 |
| 4 | Janus Henderson Investors US LLC | 2,141,936 | -168,750 | 1,232,512,813.12 | 0.6104 | 3.5252 | 03/31/2025 |
| 5 | Point72 Asset Management LP | 0 | -157,546 | 0 | 0 | 0 | |
| 6 | T. Rowe Price Associates, Inc. (IM) | 4,590,184 | -112,997 | 2,641,283,677.28 | 0.3143 | 7.5545 | 03/31/2025 |
| 7 | Morgan Stanley & Co. LLC | 498,552 | -68,144 | 286,876,791.84 | 0.0982 | 0.8205 | 03/31/2025 |
| 8 | Marshall Wace LLP | 126,774 | -64,779 | 72,948,295.08 | 0.0832 | 0.2086 | 03/31/2025 |
| 9 | Federated Global Investment Management Corp. | 107,366 | -61,086 | 61,780,543.72 | 0.4747 | 0.1767 | 03/31/2025 |
| 10 | Pictet Asset Management SA | 229,441 | -55,253 | 132,024,940.22 | 0.0898 | 0.3776 | 03/31/2025 |
Data provided by FactSet Research Systems Inc.